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Semaglutide, a GLP-1 receptor agonist originally developed for type 2 diabetes management, has demonstrated significant weight loss effects in clinical trials, with patients losing an average of 15-22% of their body weight over 68 weeks

A dose-dependent weight loss was observed in the MAD part

Participants were asked, "Have you ever had symptoms of a bladder infection (such as pain in your bladder and frequent urination) that lasted more than 3 months?" Those who gave a positive response were then asked, "When you had this condition, were you told that you had interstitial cystitis or painful bladder syndrome?" An affirmative answer to both questions was considered to define the presence of IC/BPS

This guide compares the clinical evidence on side effects across the main GLP-1 options available in the UK

10.4103/1673-5374.265562 68 SweeneyM

PMC 6440629