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We still dont understand most of the variation in response, says Ewan Pearson, professor of diabetic medicine at the University of Dundee in Scotland

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mTOR contributes to more than 700 different phosphorylation reactions including the tuberous sclerosis/TSC1 (hamartin)-TSC2 (tuberin) complex, which itself dampens the mTOR/S6K/4E-BP pathway (i.e., ribosomal protein S6 kinase 1/S6K and eukaryotic translation initiation factor 4E-binding protein/4E-BP) [18]

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