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Studies using gene array analysis have reported that GHK-Cu modulates the expression of hundreds of human genes including genes involved in tissue remodelling, inflammation regulation, DNA repair, antioxidant defence, and cellular metabolism making it a uniquely broad-spectrum research tool for studying peptide-driven gene regulation

Neuroprotection with amifostine in the first-line treatment of advanced ovarian cancer with carboplatin/paclitaxel-based chemotherapya double-blind, placebo-controlled, randomized phase II study from the Arbeitsgemeinschaft Gynkologische Onkologoie (AGO) Ovarian Cancer Study Group

One of the primary issues may be around the enzyme diamine oxidase (DAO)

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Kachroo et al., 2010)