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Metabolic effects beyond weight loss In addition to weight reduction, CagriSema has demonstrated improvements in: HbA1c Fasting glucose Triglycerides LDL cholesterol Waist circumference Blood pressure These metabolic improvements reinforce that obesity pharmacotherapy addresses systemic cardiometabolic risk, not just body weight

Gastrointestinal Side Effects and Drinking Tirzepatide commonly causes nausea, vomiting, constipation, and diarrhea during dose escalation, with symptom severity varying based on individual peptide-pathway sensitivity

5.6 Personalized medicine and holistic approaches The increasing knowledge of the gut-brain-kidney axis offers the potential for personalized treatments, especially in CKD patients

J Bone Miner Res 20 : 790798 Hanada T et al

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