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Symptoms of vitamin D toxicity are due to increased calcium levels in the blood and can include nausea, vomiting, muscle weakness, neurologic or psychiatric symptoms, pain, loss of appetite, dehydration, increased urination, excessive thirst, and kidney stones

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In vivo and in vitro studies have reported that EE itself is biotransformed for excretion mainly by glucuronidation (85%) and sulfation (12%) and that hydroxylation (mainly by CYP3A4 and CYP2A9 on C2) occurs only at low levels 22

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