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Clinicians are encouraged to apply clinical judgement alongside BMI when assessing suitability

For example, some people might respond better to Topiramate because of how it reduces appetite, while others might find Semaglutide more effective because it helps them feel full for longer periods

Early trials show it improves insulin sensitivity and fat mass

Address and rule out other potential causes, including rapid weight loss, preexisting biliary disease, or interactions with other medications

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