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7.11.12 Alpha lipoic acid (ALA), a potent antioxidant having both hydrophilic and hydrophobic properties and serving as a cofactor for several mitochondrial enzymes, represents one potential intervention for improving DPN

Indeed, in clinical practice, metformin demonstrated a variety of beneficial effects on menstrual disorder, anovulation, androgen excess, insulin resistance, and cardiovascular risk, whereas its weight loss effect is often inconsistent and transient [21, 22]

Undergone gastrointestinal surgery (gastric bypass, ileal resection) or Malabsorption diagnosis

Kajbaf, F., Arnouts, P., de Broe, M

The main reasons are side effects, a sudden stop in weight reduction, or loss of drive

S, Dervishi, E