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SURMOUNT-4 showed that patients who discontinued tirzepatide after 36 weeks of treatment regained 14.8% of body weight over the subsequent 52 weeks, compared with continued weight loss of 5.5% in those who maintained the drug

Levothyroxine dosing is influenced by body weight, with typical maintenance doses ranging from 1.6-1.8 mcg/kg/day based on ideal or lean body weight (using actual body weight in obesity may lead to overreplacement)

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doi: 10.4014/jmb.1411.11076

10.1016/S0022-3476(75)80148-X J Pediatr

Severe nausea requiring treatment discontinuation was rare in monotherapy trials, with only about 1% of participants in the REDEFINE 1 trial stopping treatment because of adverse events overall