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SUSTAIN 6, a cardiovascular outcomes trial, revealed a 26% reduction in major adverse cardiovascular events (MACE) including cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke

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This information supported the definition of a beneficial clinical effect in the renewal criteria, which was based on input from clinical experts and consistent with input received from clinician groups

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By addressing underlying metabolic dysregulation, reducing liver fat, and alleviating inflammation, tirzepatide shows potential in enhancing liver function and slowing the progression of NAFLD