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These findings suggest that longer or repeated courses of GLP-1 agonist therapy may be needed to sustain benefits and align with observations by Davies et al

Patients have reported severe abdominal pain, nausea, and vomiting that required emergency care

The lack of significant effects on renal outcomes in this population may be due to the relatively short duration of follow-up in some studies or the inclusion of patients with less severe renal impairment

No dose splitting required at any tier

Compared with groups A1, 2 and 3, the basement membrane of seminiferous tubules in the testis tissue of rats showed slight folds, atrophy and stratification