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To correct for multiple comparisons, we controlled the false discovery rate by setting Q = 1% and used the two-stage step of the method of Benjamini Krieger Yekutieli

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Decision-Making Framework Choose Nasal Spray If : Rapid onset is priority (acute injuries, pre-training) Maximum bioavailability matters for your protocol Precise dose titration is important Targeting neurological or upper respiratory applications Working with athletes needing quick recovery support Willing to manage refrigeration requirements Choose Oral Capsules If : Travel and convenience are priorities Targeting gastrointestinal healing specifically Prefer familiar supplement administration Budget constraints favor lower upfront costs Seeking longer duration of action Have nasal sensitivity or chronic congestion Personalization Factors Individual Variables to Consider : Lifestyle Patterns : Busy professionals may prefer discrete oral capsules, while home-based users might optimize with nasal sprays Therapeutic Goals : Acute injury recovery favors nasal spray

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With the opioid epidemic to over-prescribed anti-depressants, antibiotics, and sleep aids, these drugs have life altering effects for the individual