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Tirzepatide clears the body in approximately 5 days per half-life (about 25 days total clearance), while semaglutide takes approximately 7 days per half-life (about 35 days total clearance)

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[8] [9] For retatrutide specifically, follow the missed-dose guidance provided in your trial protocol or by your prescriber

A recent study from the University of Utah raised significant concerns about muscle loss in people using GLP-1 medications