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Its unique Ec domain provides a mechanistically distinct signal from systemic IGF-1 analogues, allowing researchers to study the local muscle precursor cell response independently of systemic anabolic signalling

Recently, de Schepper and co-workers, in a cross-sectional, population-based study, confirmed a strong association between LBP and IVD degeneration by finding a high prevalence of disc narrowing and osteophyte formation (two morphological features of disc degeneration) in people affected by LBP [97]

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