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Researchers view GLP-1 and GIP as incretins

Figure 2 4 Gut microbiota metabolism of dietary amino acids and its association with diabetic kidney disease 4.1 Metabolic interactions between dietary protein and gut microbiota 4.1.1 Effects of protein intake and source on gut microbiota Dietary protein serves as a crucial nutritional substrate for gut microbiota, with its intake quantity and source significantly influencing intestinal microbial composition and metabolic activity

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Trial averages at the highest dose (12 mg) reached around 24% body weight loss at 48 weeks, and around 28% at 68 weeks in the obesity plus knee osteoarthritis trial