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Open Forum Infectious Diseases, 12 (Supplement 1)

There is no good evidence for a B12 'detox' or 'toxin release', so treat that framing with caution

Furthermore, chronic overproduction of TGF1 from astrocytes and microglia leads to decreased pericyte coverage, facilitating vascular remodeling and suboptimal brain perfusion [187,188,189]

Investigations suggest it may bind to pituitary GHRH receptors, leading to cyclic AMPmediated signaling and downstream hormonal release in experimental systems