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Many people find that their tolerance decreases

Anxiolytic-like effects of 7-nitroindazole in the rat plus-maze test

The article says reduced activity tolerance during the nausea and vomiting phase can cause localized pain from immobility or postural compensation

When SAMe is low, the remethylation of homocysteine to methionine is prioritized in the cell (instead of the transsulfuration pathway).[ref] Drains on methyl groups: About 40% of methyl groups are used for creatine synthesis, so when creatine levels are higher, it can reduce the need for methyl groups

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