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A reduced incidence of Alzheimers disease was found in patients with type-2 diabetes taking exenatide [36], and a 2010 trial was launched to investigate the effects of exenatide on cognitive performance and clinical progression of Alzheimers disease [37]

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N-Acetylglucosamine 6-O-sulfotransferase-1 is required for brain keratan sulfate biosynthesis and glial scar formation after brain injury

These conditions indicate metabolic dysfunction that responds well to GLP-1 receptor agonist intervention

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