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The exclusion criteria were selected to increase internal validity (rationales are shown in ESM Table 2) and included history of cholangiocarcinoma any time before cohort entry, healthcare visit for any cancer within the previous year, as well as diagnoses of human immunodeficiency virus, hepatitis B or C, cystic disease of the liver or choledochal duct, primary sclerosing cholangitis, cystic fibrosis, end-stage illness (e.g
Michael Anson*, Zhihong Guo*, Rafael de Cabo, Titilola Iyun, Michelle Rios, Adrienne Hagepanos, Donald K
During systemic inflammation, the BBB is impacted via numerous processes, such as, activation of matrix metalloproteinases (MMPs), oxidative stress and free radical damage, and direct effects of circulating cytokines on tight junction proteins
Because every body is unique, dosing and frequency should always be guided by a licensed medical professional to ensure safety and maximize results
The insignificant sequence and period effects confirm that there were no carry-over effects, indicating a sufficient washout period between challenge weeks