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These changes include: Declining estrogen levels that promote visceral fat accumulation Accelerated loss of fat-free mass Approximately 2-3% decline in resting metabolic rate per decade after age 20 Disrupted sleep patterns that further impair metabolism GLP-1 receptor agonists offer a particularly compelling approach for addressing menopause-related weight challenges by: Directly targeting the visceral adiposity that characterizes menopausal weight gain Countering metabolic slowdown through enhanced satiety signals Improving insulin sensitivity and glucose metabolism Potentially complementing hormone replacement therapy (HRT) The relationship between GLP-1RAs and HRT deserves special attention

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Curr Dev Nutr 2017;2(3):nzy002

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The cell migration rate was calculated as the ratio of diminishing scratch area to total scratch area (normalized to 0 h)