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"Novo Nordisk A/S: Wegovy pill approved in the US as first oral GLP-1 for weight management" (Press release)

doi:10.1016/s0899-9007(96)80058-x Coviello AD, Bremner WJ, Matsumoto AM, et al

To date, most weight-loss drugs, despite their initial approval, have since been pulled from the market for unforeseen side effects that turned them into a public threat

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2+ /calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/Prolactin regulatory element binding (CaMKK/CaMKIV/PREB), increasing apolipoprotein AI (apo AI) mRNA and promoter expression, and increasing apo AI secretion, thereby mediating intracellular cholesterol efflux