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Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice

PMCID: PMC11084736

Sub-analyses from trials like LEADER (liraglutide) and REWIND (dulaglutide) have shown modest reductions in high-sensitivity C-reactive protein (hsCRP) and other inflammatory biomarkers among patients treated with these agents

doi:10.1056/NEJMoa2028395 Mosenzon O, Capehorn MS, De Remigis A, Rasmussen S, et al

Lots of factors are involved including monoamine imbalances, too little neurotrophic support, brain inflammation, and changes in how neurons connect with each other