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In addition, GLP-1RAs, reduce pancreatic islet -cell apoptosis, stimulate the proliferation and differentiation of -cells, and decrease body weight by suppressing food intake in patients with T2DM [8, 41,42,43]

However, excitement about pancreatic GLP-1 production was somewhat muted by early work in the perfused pancreas of humans (49) and rats (50) that detected mainly the inactive form of GLP-1 [GLP-1 (137) ] and, therefore, called into question the physiological relevance of pancreatic GLP-1

The reduction of parasympathetic tone can undergo tachyphylaxis with chronic GLP-1 stimulation

Provide individualized care and monitor patients

Dual-source inulin provides fermentable substrate throughout the digestive tract

This step ensures the patient has an accurate understanding and sets realistic expectations