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In addition, the mechanism of membrane fusion between virus and target cells is very conserved in different COVs, and the six-helix bundle formation between the HR1 and HR2 domains plays a key role in driving membrane fusion, which also makes this region an important target for the development of broad-spectrum viral fusion/invasion inhibitors

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The proliferative effect of DBZ can be amplified by SCFAs in small intestinal organoids, highlighting the benefits of combination therapies [198]