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[DOI] [PMC free article] [PubMed] [Google Scholar] [111].Davies MJ, Bergenstal R, Bode B, et al

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Tumor cells with mesenchymal phenotype are resistant to the dual IGF-IR/InsR inhibitor linsitinib, due to the decreased expression of IGF2 and InsR, and phosphorylation of IGF-IR/InsR in these cells [182]

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In conclusion, oral semaglutide is the first and only oral GLP-1 receptor agonist with proven cardiovascular benefits. McGuire did emphasize that injectable semaglutide is the preferred route of treatment for this drug