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Ligand-specific regulation of a binary enhancer code dictating cellular senescence

The cells were serum deprived for 24 h prior to the treatment to reduce the basal levels of phospho-Met

however, this varies from person to person

This disruption initiates a critical sequence of events: it promotes the phosphorylation of p53 and facilitates its translocation to the cytoplasm

Future anti-obesity agents for use in older adults Several novel AOMs are currently in development, or undergoing clinical trials, that will likely be available for the treatment of obesity soon, and have included older adult participants (Table 1)

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