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However, in the case of persistent HH, an improvement in MS usually requires and might be achieved by the implementation of testosterone treatment (152)

Some research suggests individuals with fatty liver may have reduced hepatic glutathione levels

Recent work suggests an interaction with the JAK-2/STAT-3 pathway, involved in the inflammatory response and cell survival, reinforcing the hypothesis of a pleiotropic mechanism of action

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Moreover, in the context of CIPN, supplementation may not be indefinite but of bounded duration in order to alleviate CIPN symptoms

Additionally, IN delivery bypasses the gastrointestinal tract and hepatic first-pass metabolism, potentially leading to improved bioavailability of oral iron chelators like DFP (Pires et al., 2009