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MMP9 secretion increases BBB permeability [46]

An association of treatment with GLP-1RA receptor agonists and DR was originally reported in the SUSTAIN-6 trial, which demonstrated a statistically significant increase in risk of new or worsening DR, with 3% incidence in the semaglutide group versus 1.8% in the placebo group (hazard ratio, 1.76

In September 2014, Dulaglutide from Eli Lilly was approved and received priority review status in China

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Furthermore, we applied Annexin-V/PI flow cytometry to differentiate and quantitatively determine viable cells [LL quadrant: Annexin V (), PI ()], early apoptotic cells (UL quadrant, Annexin V (+), PI ()], late apoptotic cells [UR quadrant, Annexin V (+), PI (+)], and necrotic cells [LR quadrant, Annexin V (), PI (+)]

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