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Very rarely, allergic reactions or mild diarrhea can occur

Ozempic 0.5 mg solution for injection in pre-filled pen Summary of Product Characteristics (SmPC)

Science 343 , 541544 (2014)

Quick Answer: Semaglutide can cause localized injection site reactions in approximately 1.42.4% of patients, and rare serious hypersensitivity reactions including rash and angioedema have been reported, though widespread skin sensitivity is not a common side effect

Dual Delivery Methods : Available as either a nasal spray or subcutaneous injection, giving patients flexibility in treatment style and onset timing