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Clinical and experimental evidence confirms a U-shaped relationship between copper levels and blood pressure, indicating that both copper deficiency and excess are associated with a higher prevalence of hypertension [213]

developed a model of Ox-LDL-induced ferroptosis in HUVECs, showing that CTRP13 intervention increased antioxidant enzyme expression, preventing AS and protecting endothelial cells from ferroptosis ( / mice by reducing mitochondrial damage, boosting glutathione and superoxide dismutase levels, and decreasing LPO and MDA levels

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The Journal of clinical investigation , 92 (5), 23682376

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