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Heavy drinking may also worsen nausea and vomiting
Disruptions in this axis, driven by gut dysbiosis, have been implicated in the pathogenesis of a wide range of neurodegenerative and neuropsychiatric disorders
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It notes that mild to moderate hepatic or renal impairment may prolong drug exposure, and that age-related decline in kidney function can slow clearance, particularly in patients over 65
Wang Z, Li X, Spasojevic I, Lu L, Shen Y, Qu X, et al