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Cycle Duration 52 weeks (26-week weight-loss + 26-week maintenance) Repeatable Single cycle Suggested Bloodwork (4 tests) DXA body composition scan When: Baseline and 26 weeks Why: Measure lean mass and fat mass changes CMP (Comprehensive Metabolic Panel) When: Baseline Why: Liver and kidney function baseline Lipid panel When: Baseline and 26 weeks Why: Monitor cardiovascular risk factors Anti-drug antibodies When: Periodic Why: Monitor for immunogenicity Key Considerations Investigational monoclonal antibody available only through clinical trials

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An important part of the redox hub the core linking the cellular energy system and the net of signalling pathways (Foyer and Noctor 2011) are compounds with cysteinyl (Cys) residues