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Similarly, urate is also neuroprotective by enhancing GSH expression through activation of the Akt/GSK3/NRF2/GCLC pathway in mutant SOD1 G85R cellular and Drosophila models (Zhang et al., 2019b)

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Electrolyte imbalances, particularly hyponatremia or hypokalemia, may accompany dehydration and further contribute to weakness and tiredness