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Genetic ablation of -arrestin2 completely prevented the antidyskinetic effect of these nanocarriers, while its overexpression potentiated this therapeutic effect
Results Deubiquitinated arrestin3 and G translocate to the nucleus under the desensitization conditions of D2-like receptors It has previously been reported that dopamine D 3 receptors (D 3 Rs) undergo desensitization in response to cell pretreatment with 100 nM quinpirole (Quin), but do not show the same response when pretreated with 30 nM dopamine (DA)
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Astaxanthin: A potential therapeutic agent in cardiovascular health
Tissue proteins (15 g) were separated by electrophoresis on a NuPAGE 4-12% Bis-Tris gel (Invitrogen, Carlsbad, CA, USA) and transferred to a PVDF membrane
To model this plastic behavior, 3D hydrogels composed of reconstituted basement membrane and alginate are used
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