& Krebs, M
Hypoglycaemia risk: Retatrutide, like other incretin-class agents, stimulates insulin secretion in a glucose-dependent manner, meaning the risk of hypoglycaemia with monotherapy in otherwise healthy individuals is generally low
Furthermore, in a Phase 1 randomized, double-blind, placebo-controlled clinical study (NCT04478708) in patients with obesity, adult obese subjects received either a single ascending dose (SAD) or multiple ascending doses (MAD) of AMG 133, compared with a placebo group
More information The tablets are white to light yellow, oval and debossed with 3, 7 or 14 on one side and novo on the other
8 Based on data from the MAESTRO-NASH trial, resmetirom demonstrated histological benefits with a number needed to treat of five for the resolution of MASH and 8.5 for fibrosis regression, 9 thus posing significant economic challenges
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