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In this study, they found that DNA polymerase (Pol ) regulated RA pathogenesis through STING-NF-B signaling-induced macrophage pyroptosis (65)

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VSMC proliferation and intimal thickening also predispose individuals to oscillatory or low blood flow, which have been shown to induce leukocyte adhesion, enhanced vascular permeability, LDL oxidation, and atherosclerotic plaque formation 42,43,44

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Importantly, inhibition of FOXOs in such cells tipped the balance from senescence towards apoptosis

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