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Additionally, the activation of TGR5 and FXR (receptors for BAs) inhibits the effector functions of macrophages and promotes their polarization toward the anti-inflammatory M2 phenotype (49)

In another study, Salaga et al

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References: Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial

Potential Side Effects and Safety Considerations The most common side effects are gastrointestinal including nausea, vomiting, and diarrhoea and are most pronounced during dose escalation

Inhibition of arachidonic acid metabolism and its implication on cell proliferation and tumour-angiogenesis