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Finally, 10-formyl-THF can be converted back to THF via the actions of the cytoplasmic ALDH1L1 (aldehyde dehydrogenase 1 family member L1) encoded enzyme

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This results in a skin whitening effect

p53 also promotes the expression of genes essential for synthesizing and recycling GSH, including glutamate-cysteine ligase modifier subunit (GCLM) and glutamate-cysteine ligase catalytic subunit (GCLC), as well as those involved in restoring oxidized GSH to its reduced state (139141)

We demonstrated that the ferroptosis inhibitors Fer-1 and Lip-1 protected against cell death induced by GSH depletion

Sci Rep 15 , 16510 (2025)