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Clinical trials assessing GLP-1 RAs for weight loss rarely report facial fat loss as an adverse effect

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Differentiating between cardiac chest pain and other causes in patients taking tirzepatide requires careful clinical assessment

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1 Key results: Average weight loss: -14.9% of body weight (vs -2.4% with placebo) 86.4% achieved at least 5% weight loss 69.1% achieved at least 10% weight loss 50.5% achieved at least 15% weight loss Wegovy 7.2 mg: the STEP UP trial The STEP UP trial compared semaglutide 7.2 mg with the standard 2.4 mg dose in adults with obesity over 72 weeks