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Glutathiones unique molecular structure contains a special sulfhydryl group with -240 mV redox potential
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As a result, the physiological regulation of Keap1-Nrf2 is lost, and free NAPQI reacts with protein sulfhydryl groups to form APAP adducts (Figure 1)
This sodium-independent antiporter is composed of two subunits: xCT (gene name SLC7A11 ), a subunit responsible for the amino acid exchange, and a chaperone CD98 (gene name SLC3A2 )
