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Declaration of Conflicting Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Robin P

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"Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation: a double-blind, vehicle-controlled comparison of 0.1% and 0.025% tretinoin creams." Archives of dermatology 131.9 (1995): 1037-1044

In that study it was shown that both PIO and TOFO for 24 weeks significantly improved hepatic steatosis based on the absolute change in MRI-proton density fat fraction (MRI-PDFF), as well as ALT levels, with the differences being statistically insignificant between the two drugs

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