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Cureus, 16(3), e55771

This problem is compounded by the intrinsically dynamic character of the 7TM bundle 14, 15 and the relative instability of GPCR complexes, such as with G proteins 16 or arrestins 17 , often resulting in conformational variability or even dissociation during cryo-EM specimen preparation

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Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimers disease mouse model

Ozempic was first FDA-approved in 2017, and we're still learning about long-term effects