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However, they differ in a key way: tirzepatide is a dual agonist (GLP-1 and GIP), while retatrutide is a triple agonist (GLP-1, GIP, and GCG)

Circulation 142:12051218 Hernandez AF, Green JB, Janmohamed S, DAgostino RB Sr, Granger CB, Jones NP, Leiter LA, Rosenberg AE, Sigmon KN, Somerville MC, Thorpe KM, McMurray JJV, Del Prato S (2018) Harmony Outcomes committees and investigators

However, it is recommended to escalate the dose slowly, as semaglutide is associated with gastrointestinal side effects

TH17 cells then produce their own cytokines, primarily IL-17A and IL-22, which act directly on keratinocytes, the cells that make up the outer layer of skin