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Novo is also launching higher-dose formulations, developing companion therapies, and pursuing additional indications (cardiovascular prevention, kidney disease)
Of note, in the STEP 1 extension trial, participants regained roughly two-thirds of their lost weight within a year of stopping semaglutide, and improvements in blood pressure, cholesterol, and glucose largely reversed
GLP-1 is produced in L cells in the distal intestine, while GIP is synthesized within K cells in the duodenum
It may also appeal to individuals focused on long-term metabolic health who want to support the biological systems that underlie healthy weight management and blood sugar regulation
Survodutide and mazdutide round out the pipeline