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PMC 9225589

One, GLP-1s may have treated her binge eating, [but] two, her binge eating has a function. It was a single case, but it piqued Kleppes curiosity

Any organ system can be affected, and severity can range from mild grade 12 to severe grade 3-4 toxicities

Although these drugs have been used to treat type 2 diabetes for nearly two decades, it was not until 2021 that the US FDA approved them for treating obesity

Quick answer: In the Phase 2 clinical trial (Jastreboff et al., 2023, New England Journal of Medicine ), retatrutide was given by once-weekly subcutaneous injection across a 112mg range