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gingivalis FimA can activate the interaction of CXC-chemokine receptor 4 (CXCR4) and TLR2 in macrophages and induce cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) signaling

L., & Glosli J

10.1007/s13311-017-0589-9 Neurotherapeutics 39 LiN.JiangW.WangW.XiongR.WuX.GengQ

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These non-enzymatic antioxidants, whether from diet or synthesized for therapy, vary in effectiveness against human cancer, showing both successes and failures in use [62,63,64]

Figure 2 In eukaryotic cells, RES are implicated in many pathophysiological processes and modulate signaling pathways (Mackay and Knock, 2015)