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Phase 2 trial (NEJM, 2023) The landmark Phase 2 trial, published in the New England Journal of Medicine, randomized 338 adults with obesity to receive weekly subcutaneous retatrutide at doses of 1 mg, 4 mg, 8 mg, or 12 mg, or placebo, for 48 weeks

Any cloudiness, discoloration, or persistent particles indicates degradation

A research peptide is only ever as good as its certificate of analysis

Persistent injuries can be frustrating for both patients and providers

Other considerations include hypoglycemia (most common concern), possible local tissue effects at injection sites, unknown long-term consequences of repeated local IGF-1 surges, and potential for organ growth with chronic use near specific organs

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