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The Phase 3 study enrolled nearly 2,000 people with severe obesity and heart disease, with or without diabetes

Intraduodenal administration of sucrose, sucralose, and the artificial sweetener PALSWEET each significantly increase lymph GLP-2 output compared to saline control (Sato et al., 2013)

Other considerations include side effects (such as nausea or digestive upset) and cost

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