This leads to decreased peripheral and central 5-HT levels, impaired receptor function, reduced concentrations of tryptophan and 5-HT (232), worsened symptoms of affective disorders, elevated levels of tryptophan catabolites (233, 234), and increased concentrations of toxic metabolites in the CNS (235)
These effects ultimately result in membrane destabilization, enzymatic inhibition, and dysfunction of signal transduction networks, causing metabolic imbalances that determine the threshold between adaptation and cell death
Minimizing stress levels, exercising regularly, increasing your intake of whole foods, cutting out heavily processed, high cholesterol foods and giving up unhealthy habits like smoking or drinking are just a few other natural ways to keep cholesterol levels under control and support better health
For ordinal endpoints, NNTs derived by dichotomously collapsing scales are easily calculated but almost always underestimate the amount of benefit a treatment confers
Focus on sulfur-rich foods, which provide the cysteine necessary for synthesis
Will put up with the tendonitis and early arthritic joints for now
