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Itching and skin rash are among the most common

An in vitro model based on human brain endothelial cells (hBECs) first appeared in 1985 (Pardridge et al., 1985)

As summarized in Table S1, the level of evidence is still low, derived mainly from in vitro studies, animal models, and small patient cohorts, with only limited data from RCT available

Moreover, early intervention is key

Haowen Sun, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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