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For the heterogeneity of glutamine metabolism among tumors, the first factor to consider is biological factors

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For this to become a fact, however, further carbon tracer, protein and gene expression studies, together with large patient protocols are needed to reveal the exact role of IGF-1 in the whole system

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Interestingly, MECP2 undergoes dynamic O-GlcNAc modification at threonine 203 (T203), and disruption of O-GlcNAcylation at this specific site in MECP2 impairs dendritic development and dendritic spine maturation in cultured hippocampal neurons, and dysfunction in synaptic transmission in the mouse cerebral cortex [117]

10.1038/s41598-018-33661-y 12 BoccardiV.BaroniM.MangialascheF.MecocciP